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SUMMARY:02/05 : LE 13H DE ANNE RIOS @ RESTORE
UID:https://restore-lab.fr/02-05-le-13h-de-anne-rios-restore/
LOCATION:RESTORE Bâtiment INCERE, 4bis avenue hubert curien 31100 Toulouse
DTSTAMP:20240502T130000
DTSTART;TZID=Europe/Paris:20240502T130000
DTEND;TZID=Europe/Paris:20240502T140000
DESCRIPTION:Organoid human cancer immunity model in motion
		Dr Anne Rios will present a dynamic 3D imaging and integrated
transcriptomics platform; BEHAV3D5, that has been developed to exploit
immune-organoid co-cultures for understanding and improving the dynamic
mode-of-action of engineered T cells in a patient personalized manner.
Applied to various solid tumor types modeled with patient derived organoids
and emerging T cell therapies, BEHAV3D revealed a high heterogeneity in
targeting efficacy and functional behavior. Combined with a module of
Behavior-guided sc transcriptomics, they could identify the gene signature
of the most potent ‘serial killer’ T cells as well define combinatorial
treatment to prime immunotherapy-mediating killing. Thus, BEHAV3D holds
promise for improving dynamic solid tumor-targeting of T cell
immunotherapies at patient population scale.Over the years Dr. Rios’
research interests have focused on advancing 3D imaging technologies to
explore developmental processes, stem cell biology and cancer progression.
As tenured group leader and head of the imaging center at the Princess
Máxima Center for pediatric oncology and principal investigator of the
Oncode cancer institute of excellence in the Netherlands, her research
direction has now centered towards understanding and improving cancer
immunotherapies. She leads an interdisciplinary team with a strong emphasis
on technological advancements, combining organoid technology, tissue
imaging, and vision-based multi-omics to identify new therapeutic targets
and factors that influence treatment outcomes for pediatric tumors and
breast cancer.		
							
									Lien teams								
					
		Pour en apprendre davantage		
																										
		Dr Anne RIOS is the tenured group leader and head of the imaging center
at the Princess Máxima Center for pediatric oncology and principal
investigator of the Oncode cancer institute of excellence in the
Netherlands		
							
									mail
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