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La recherche

Restore accueille des équipes de recherche ainsi que des équipes de recherche partenaires issues d'autres laboratoires. Cette dynamique permet de favoriser l'interdisciplinarité.

Les équipes

Eq. 1 : STROMAGICS​​

Réparer/Régénérer via la circulation des cellules stromales mésenchymateuses entre les tissus

Eq. 2 : FLAMES​​

Contrôle de l’inflammaging par le dialogue cellules stromales mésenchymateuses / Macrophages

Eq. 3 : METABOLINK

Interactions métaboliques et perte de fonctions liées à l’âge

Eq. 4 : GOT-IT​​

Auto-organisation guidée pour le développement de thérapies innovantes

Les équipes partenaires

IMFT
Reactive Flow Modeling (IMFT)
The team 'Reactive flow modeling' has an established interdisciplinary experience in the domain of image/model coupling from cell to organ-scale such as flow modeling and its relationship with metabolic issues, from cell to entire-organ scale, either inside in-silico experiments or ex-vivo/in-vivo tissues. The team is concern by gathering together relevant 3D images (e.g optical, acoustical) related to the intimate tissue physiology with meso-scale modeling in order to reach a better understanding of integrated couplings, in various organs. The goal inside RESTORE is to develop this expertise to help understanding tissue heterogeneity, identify relevant couplings, so as to help understanding the tissue remodeling and aging. Furthermore, the expression of flux modeling with metabolomic analysis is a topic of interest for future research inside RESTORE, based upon the idea that cells response are coupled to their local (possibly complex) environment. The team uses and develop dedicated image-processing workflow to address practical issues related to (possibly huge) 3D image post-processing either with the aim of reaching state of the art methods.
F. Plouraboué (DR CNRS ), G. Debenest (PR INPT ), P. Keemmel (post-doc ), J. Duchamp (PhD)
IRIT
IRIT (SIG & REVA)
LHFA
AMoTIS (LHFA)
The projects developed by the AMoTIS team are related to its expertise: Organic Synthesis. Thus the goal of our projects is the design of new ways to generate molecules in general with a special emphasis on fluorescent compounds and isotopic labelling. The latter is focused on radiofluorination within the PiR2 consortium (EG in charge of the radiochemical facilities). Non radioactive isotopic labelling design to enhance NMR signals (for example) is also foreseen. Toward these goals we are developing synthetic approaches and new tools to ease the transfer from the chemistry bench to biological and medical applications. Our chemical research is thus providing the different teams of RESTORE with new imaging tools via a direct interaction with the R&D structure of the Technological Facilities of RESTORE.
E. GRAS (CR CNRS ), M. Danel (IR – UPS), N. Jean Bart (PhD), J. Beuscart (PhD).
LAAS
ELiA (LAAS)
ELiA’s team aims at developing interdisciplinary research projects at the interface between Micro/Nanotechnologies, biology, biophysics and medical applications. ELiA investigates cutting edge technologies for the study and fabrication of: Bio-interfaces, 2D/3D biomolecular and cellular architectures, and analytical devices. Applications target the study of sub-cellular mechanisms, the development of microdevices for the detection and analysis of circulating biomarkers, as well as the fabrication of cell culture micro-environments and tissue models.
L. Malaquin (DR CNRS), C. Vieu (Pr INSA), C. Thibault (MdC INSA), G. Eke (Post-Doc), R. RIesco (PhD), C. Blatché (IR)
IMT
Mathematics for Imaging (IMT)
The primary objective of the members of this team is to advance the foundations of applied mathematics in order to answer practical questions that are still beyond the reach of current theories As part of the RESTORE project, our team could provide support for the following questions such as Automated image analysis, Modelling of biological systems or Improvement of imaging systems.
P. Weiss (CR CNRS), J. Kahn (CR CNRS), F. de Gournay (MCF), E. Soubies (CR CNRS)

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