Our team combines organic chemistry and heterochemistry to develop new molecules and methods for biology.
We focus in particular on incorporating fluorinated fragments for fluorine-18 radiolabelling for in vivo imaging using positron emission tomography (PET). We are also exploring dual, even theranostic approaches, combining fluorescence properties with therapeutic potential. These themes are naturally associated with approaches involving bioconjugation to biological macromolecules.
We also aim to exploit biomolecules and advanced molecular structures as environments for catalysis that promotes structural complexity. In particular, the use of carbene molecules to carry out pericyclic reactions in a structured environment is one of our favourite topics.
Toward these goals we are developing synthetic approaches and new tools to ease the transfer from the chemistry bench to biological and medical applications.
Our chemical research is thus providing the different teams of RESTORE with new imaging tools via a direct interaction with the R&D structure of the Technological Facilities of RESTORE.
E. GRAS (CR CNRS ), M. Danel (IR – UPS), N. Jean Bart (PhD), J. Beuscart (PhD).
