Main Publications (5 last years) :

• mosna reveals different types of cellular interactions predictive of response to immunotherapies and survival in cancer.

Coullomb A, Foulon C, van Haastrecht B, Monsarrat P, Pancaldi V. Mol Cell Proteomics. 2026 Feb 25:101536. doi: 10.1016/j.mcpro.2026.101536.

• Age-related evolution of human gingiva towards a fibrotic-like connective phenotype.

Cecchin-Albertoni C, Deny O, Pieruccioni L, Ousset M, Oreja-Fuentes P, Arnaud E, Guissard C, Casteilla L, Planat-Bénard V, Kémoun P, Monsarrat P. Sci Rep. 2025 Nov 25;15(1):45298. doi: 10.1038/s41598-025-29089-w.

• A single-graph visualization to reveal hidden explainability patterns of SHAP feature interactions in machine learning for biomedical issues

Félix Furger , Miguel Thomas , Julien Aligon, Emmanuel Doumard, Cyrille Delpierre, Louis Casteilla, Paul Monsarrat. Plos Comp Sys. 2025 Sep,  https://doi.org/10.1371/journal.pcsy.0000060

• EMito-Metrix enables automated evaluation of mitochondrial morphology across species.

Morin E, Doumard E, Hartnell LM, Salegi Ansa B, Leduc-Gaudet JP, Quillien A, Nakhle J, Ethuin S, Goudounèche D, Payré B, Soldan V, Balor S, Mattout A, Rouquette J, Dubois L, Sengenès C, Planat V, Casteilla L, Yart A, Dray C, Aligon J, Ferrucci L, Duchesne É, Hussain SNA, Gouspillou G, Formentini L, Mourier A, Baris OR, Valet P, Parpex H, Monsarrat P, Vigneau M, Pradère JP. Nat Metab. 2025 Nov;7(11):2179-2182. doi: 10.1038/s42255-025-01400-z.

• Identification of Functional Cellular Markers Related to Human Health, Frailty and Chronological Age.

Brodeau C, Joly C, Chekroun A, Nakhle J, Blase V, Espagnolle N, Dray C, Yart A, Planat V, Tertrais M, Fassy J, Guyonnet S, Lu WH, de Souto Barreto P, Teste O, Tremblay-Franco M, Tanner KT, Cohen AA, Carriere A, Casteilla L, Ader I; IHU HealthAge/Open Science group. Aging Cell. 2025 Sep;24(9):e70153. doi: 10.1111/acel.70153

• Discernibility in explanations: Designing more acceptable and meaningful machine learning models for medicine.

Wang H, Aligon J, May J, Doumard E, Labroche N, Delpierre C, Soulé-Dupuy C, Casteilla L, Planat-Benard V, Monsarrat P. Comput Struct Biotechnol J. 2025 Apr 23;27:1800-1808. doi: 10.1016/j.csbj.2025.04.021.

• Periodontitis therapy using autologous adipose-derived stromal cells: a double-blind randomized controlled clinical trial in an aged canine model.

Paul Monsarrat , Sara Laurencin-Dalicieux , Geraldine Jourdan, Vincent Blasco-Baque , Marion Bourdens , Emilie Bouhsira , Chiara Cecchin-Albertoni , Fabrice Conchou , Pascale Loubieres , Matthieu Minty , Emmanuelle Arnaud , Sophie Dupuis-Coronas, Christophe Guissard , Jade Chaumont , Louis Casteilla , Isabelle Raymond-Letron , Valerie Planat-Benard , Philippe Kemoun. 2024 Oct; doi :10.1016/j.jcyt.2024.10.012

• A computational model reveals an early transient decrease in fiber cross-linking that unlocks adult regeneration.

Pacary A, Peurichard D, Vaysse L, Monsarrat P, Bolut C, Girel A, Guissard C, Lorsignol A, Planat-Benard V, Paupert J, Ousset M, Casteilla L. NPJ Regen Med. 2024 Oct 15;9(1):29. doi: 10.1038/s41536-024-00373-z.

• Acceptability of Allogeneic Mesenchymal Stromal Cell-Based Tissue Engineering for the Treatment of Periodontitis: A Qualitative Study in France.

Riazuelo L, Planat-Bénard V, Vinel A, Laurencin S, Casteilla L, Kémoun P, Marty M, Monsarrat P. Int Dent J. 2025 Apr;75(2):840-848. doi: 10.1016/j.identj.2024.07.1208

• Fibre crosslinking drives the emergence of order in a three-dimensional dynamical network model.

Chassonnery P, Paupert J, Lorsignol A, Séverac C, Ousset M, Degond P, Casteilla L, Peurichard D. R Soc Open Sci. 2024 Jan 31;11(1):231456. doi: 10.1098/rsos.231456.

• Scalable Generation of Pre-Vascularized and Functional Human Beige Adipose Organoids.

Escudero M, Vaysse L, Eke G, Peyrou M, Villarroya F, Bonnel S, Jeanson Y, Boyer L, Vieu C, Chaput B, Yao X, Deschaseaux F, Parny M, Raymond-Letron I, Dani C, Carrière A, Malaquin L, Casteilla L. Adv Sci (Weinh). 2023 Sep 20:e2301499. doi: 10.1002/advs.202301499.

• Explainable machine learning framework to predict personalized physiological aging.

Bernard D, Doumard E, Ader I, Kemoun P, Pagès JC, Galinier A, Cussat-Blanc S, Furger F, Ferrucci L, Aligon J, Delpierre C, Pénicaud L, Monsarrat P, Casteilla L. Aging Cell. 2023 Aug;22(8):e13872. doi: 10.1111/acel.13872.

• Characterization and Safety Profile of a New Combined Advanced Therapeutic Medical Product Platelet Lysate-Based Fibrin Hydrogel for Mesenchymal Stromal Cell Local Delivery in Regenerative Medicine.

Canceill T, Jourdan G, Kémoun P, Guissard C, Monsef YA, Bourdens M, Chaput B, Cavalie S, Casteilla L, Planat-Bénard V, Monsarrat P, Raymond-Letron I. Int J Mol Sci. 2023 ; 24(3):2206. doi: 10.3390/ijms24032206

• Periostin Plasma Levels and Changes on Physical and Cognitive Capacities in Community-Dwelling Older Adults.

Sánchez-Sánchez JL, Ader I, Jeanson Y, Planat-Benard V, Vellas B, Casteilla L, de Souto-Barreto P. J Gerontol A Biol Sci Med Sci. 2023 ; 78(3):424-432. doi: 10.1093/gerona/glac226.

• A quantitative approach for the comparison of additive local explanation methods.

Doumard E, Aligon J, Escriva E, Excoffier JB, Monsarrat P , Soulé-Dupuy S. Information Systems, 2023

• A Spectral Principal Component Analysis-Based Framework for Composite Hard/Soft Tissue Fluorescence Image Investigation.

Piriou M, Lorenzo C, Raymond-Letron I, Coronas-Dupuis S, Pieruccioni L, Rouquette J, Guissard C, Chaumont J, Casteilla L, Planat-Benard V, Kemoun P, Monsarrat P. Front Physiol. 2022 ; 13:899626. doi: 10.3389/fphys.2022.899626.

• Systemic Periodontal Risk Score Using an Innovative Machine Learning Strategy: An Observational Study.

Monsarrat P, Bernard D, Marty M, Cecchin-Albertoni C, Doumard E, Gez L, Aligon J, Vergnes JN, Casteilla L, Kemoun P. J Pers Med. 2022 ; 12(2):217. doi: 10.3390/jpm12020217.

• Pain sensing neurons promote tissue regeneration in adult mice.

Rabiller L, Labit E, Guissard C, Gilardi S, Guiard BP, Moulédous L, Silva M, Mithieux G, Pénicaud L, Lorsignol A, Casteilla L, Dromard C. NPJ Regen Med. 2021 ; 6(1):63. doi: 10.1038/s41536-021-00175-7.

• Healthy Aging Biomarkers: The INSPIRE’s Contribution.

Ader I, Pénicaud L, Andrieu S, Beard JR, Davezac N, Dray C, Fazilleau N, Gourdy P, Guyonnet S, Liblau R, Parini A, Payoux P, Rampon C, Raymond-Letron I, Rolland Y, de Souto Barreto P, Valet P, Vergnolle N, Sierra F, Vellas B, Casteilla L. J Frailty Aging. 2021 ; 10(4):313-319. doi: 10.14283/jfa.2021.15.

• Driving regeneration, instead of healing, in adult mammals: the decisive role of resident macrophages through efferocytosis.

Rabiller L, Robert V, Arlat A, Labit E, Ousset M, Salon M, Coste A, Da Costa-Fernandes L, Monsarrat P, Ségui B, André M, Guissard C, Renoud ML, Silva M, Mithieux G, Raymond-Letron I, Pénicaud L, Lorsignol A, Casteilla L, Dromard Berthézène C, Cousin B. NPJ Regen Med. 2021 ; 6(1):41. doi: 10.1038/s41536-021-00151-1.

• The INSPIRE Bio-Resource Research Platform for Healthy Aging and Geroscience: Focus on the Human Translational Research Cohort (The INSPIRE-T Cohort).

Guyonnet S, Rolland Y, Takeda C, Ousset PJ, Ader I, Davezac N, Dray C, Fazilleau N, Gourdy P, Liblau R, Parini A, Payoux P, Pénicaud L, Rampon C, Valet P, Vergnolle N, Andrieu S, de Souto Barreto P, Casteilla L, Vellas B. J Frailty Aging. 2021;10(2):110-120. doi: 10.14283/jfa.2020.3

• Find all our publications here.

• The oral organ: A new vision of the mouth as a whole for a gerophysiological approach to healthy aging.

Cecchin-Albertoni C, Deny O, Planat-Bénard V, Guissard C, Paupert J, Vaysse F, Marty M, Casteilla L, Monsarrat P, Kémoun P. Ageing Res Rev. 2024 Aug;99:102360. doi: 10.1016/j.arr.2024.102360

• A gerophysiology perspective on healthy ageing.

Kemoun P, Ader I, Planat-Benard V, Dray C, Fazilleau N, Monsarrat P, Cousin B, Paupert J, Ousset M, Lorsignol A, Raymond-Letron I, Vellas B, Valet P, Kirkwood T, Beard J, Pénicaud L, Casteilla L. Ageing Res Rev. 2022 ; 73:101537. doi: 10.1016/j.arr.2021.101537

• The nervous system and adipose tissues: a tale of dialogues.

A Lorsignol, L Rabiller, E Labit, L.Casteilla, L Pénicaud. American Journal of Physiology-Endocrinology and metabolism. doi.org/10.1152/ajpendo.00115.2023

• Periodontal Cell Therapy: A Systematic Review and Meta-analysis.

Dubuc A, Planat-Bénard V, Marty M, Monsarrat P, Kémoun P. Adv Exp Med Biol. 2022 ; 1373:377-397. doi: 10.1007/978-3-030-96881-6_20.

• Editorial: MSC Communication in Physiological and Pathological Settings.

Bourin P, Gimble JM, Casteilla L, Salgado A. Front Cell Dev Biol. 2022 ; 10:909550. doi: 10.3389/fcell.2022.909550.

• Cell Aggregate Assembly through Microengineering for Functional Tissue Emergence.

Eke G, Vaysse L, Yao X, Escudero M, Carrière A, Trevisiol E, Vieu C, Dani C, Casteilla L, Malaquin L. Cells. 2022 ; 11(9):1394. doi: 10.3390/cells11091394.

• Tissue Regeneration: The Dark Side of Opioids.

Berthézène CD, Rabiller L, Jourdan G, Cousin B, Pénicaud L, Casteilla L, Lorsignol A. Int J Mol Sci. 2021 ; 22(14):7336. doi: 10.3390/ijms22147336.

• Lactate Fluxes and Plasticity of Adipose Tissues: A Redox Perspective.

Lagarde D, Jeanson Y, Portais JC, Galinier A, Ader I, Casteilla L, Carrière A. Front Physiol. 2021 ; 12:689747. doi: 10.3389/fphys.2021.689747.

• MSCs and Inflammatory Cells Crosstalk in Regenerative Medicine: Concerted Actions for Optimized Resolution Driven by Energy Metabolism.

Planat-Benard V, Varin A, Casteilla L. Front Immunol. 2021 ; 12:626755. doi: 10.3389/fimmu.2021.626755.

• Endogenous Mobilization of Mesenchymal Stromal Cells: A Pathway for Interorgan Communication?

Girousse A, Mathieu M, Sastourné-Arrey Q, Monferran S, Casteilla L, Sengenès C. Front Cell Dev Biol. 2021 ; 8:598520. doi: 10.3389/fcell.2020.598520.

• DIGITAL TISSUE REPAIR MODEL – WO2025133663 –

Peurichard D, Casteilla L, Ousset M, Lorsignol A, Paupert J, Vaysse L, Pacary A

• INTERFACE DEDICATED TO PERSONALISED PHYSIOLOGICAL AGE PREDICTION (PPA) – IDDN.FR.001.160001.000.S.C.2024.000.31230 –

Casteilla L, Aligon J, Monsarrat P, Furger F

• METHODS FOR PREDICTING THE HEALTH STATE OF A SUBJECT FROM FIBROBLASTS – EP24306153.8 (2024) –

Ader I, Guyonnet S, Vellas B, Casteilla L, Brodeau C

• METHOD FOR PREPARING A 3D PREVASCULARISED ADIPOSE TISSUE CONSTRUCT AND ITS USES – WO2024160980 –

Casteilla L, Carrière A, Malaquin L, Dani C, Vaysse L, Escudero M, Eke G 

• PROCESSES FOR GENERATING PREVASCULARISED 3D CELL AGGREGATES -WO2024133285 –

Casteilla L, Carrière A, Malaquin L, Dani C, Vaysse L, Escudero M, Eke G

• METHOD FOR IDENTIFYING REACTIVE OXYGEN SPECIES – EP4439067 (2024) –

Coustham C, Merabet N, Bordeneuve-Guibe J, Davezac N

• METHOD FOR DETERMINING THE PHYSIOLOGICAL AGE OF A SUBJECT – WO2023180436 –

Casteilla L, Ader I, Kemoun P, Aligon J, Monsarrat P, Cussat-Blanc S, Bernard D, Doumard E (2023)

• PROCESS TO OBTAIN HUMAN BROWN/BEIGE ADIPOCYTES – WO2017009263 –

 Deschaseaux F, Guilloton F, Muller S, Carrière A, Casteilla L, Sensebé L.

• MULTIPLE SAMPLE HOLDER FOR SPIM – USD797831S (2017), EP002624197 (2015) –

Lorenzo C, Lobjois V, Ducommun B.

• USE OF CELLS DERIVED FROM ADIPOSE TISSUE TO INDUCE THE FORMATION OF A FUNCTIONAL VASCULAR NETWORK – WO2005025584 –

Casteilla L, Silvestre JS, Planat-Benard V, Levy B, Penicaud L, Tedgui A