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PhD - PR UPS-UT3
Louis Casteilla is full professor at animal physiology in the Faculty of Science and Engineering of Toulouse III university. He is the co-leader of RESTORE Institute Team 4. For his PhD, his first work was on the development and plasticity of adipose tissues. He co-discovered and patented with V Planat in 2004 the great regenerative angiogenic properties of adipose derived stroma/stem cells (ASC). He translated this discovery to the bedside for the first clinical trial to test the effect of ASC on critical limb ischemia . From this seminal work, he has been focused his interest and investigations on regeneration in adult mammals and the development of ASC based ATMP. He set-up and co-manages with V Planat-Benard the unique quality control facility of the French infrastructure EcellFrance dedicated to the development of MSC-based ATMP. Recent work aims to decipher the decisive rules that govern the maintain and the restoration of tissue structure and function during the aging process  through integrated approaches and numerical model development.
 Plasticity of human adipose lineage cells toward endothelial cells: physiological and therapeutic perspectives. Planat-Bénard V. et al. Circ. 2004. doi: 10.1161/01.CIR.0000114522.38265.61
 Aging-related decrease of human ASC angiogenic potential is reversed by hypoxia preconditioning through ROS production. De Barros S. et al. Mol. Ther. 2013. doi: 10.1038/mt.2012.213.
 A phase I trial: the use of autologous adipose-derived stroma/stem cells to treat patients with non-revascusuclarizable Critical Limb Ischemia. Bura-Rivière A. et al. Cytotherapy, 2014. doi: 10.1016/j.jcyt.2013.11.011
 A gerophysiology perspective on healthy ageing. Kemoun P et al. Ageing Res Rev. 2022. doi: 10.1016/j.arr.2021.101537