Organs/tissues are ecosystems resulting from a dynamic coordination between the parenchymal compartment (specific element of each organ in relation to its function) and the mesenchymal compartment (transversal element providing the most appropriate support and environment for any organ). This latter plays a fundamental role in tissue architecture which supports optimal organ functions. GOT-IT focuses its research on this architecture, the associated mechanical constraints, and at the cellular level studies mesenchymal stem/stromal cells (MSC) as an orchestrator and key indicator of tissue homeostasis.

This multidisciplinary group proposes an original and holistic approach from the creation of numerical and micro-physiological models to the setting up of clinical trials. To do so, the team relies on state-of-the-art technologies such as mechanobiology (AFM), biophotonics (light sheet microscopy, spectral analysis, …etc), 3D tissue engineering and biomaterials. Moreover, GOT-IT members have set up the unique ISO standards French platform for quality control of MSCs as well as the unique European academic platform labelled for bio-distribution and biosafety studies of ATMPs (LabHPEC) within national infrastructure ECellFrance.

Our team has also played a key role in the development and structuring of the INSPIRE scientific project, which aims to better understand human functional decline and to propose rejuvenative therapies to prevent elderly dependency.