A multidisciplinary approach to study tissue degeneration and regeneration processes in adult mammals and during aging
Set up Advanced therapy medicinal products (ATMP) for regenerative and rejuvenating strategies
Organs/tissues are ecosystems resulting from a dynamic coordination between the parenchymal compartment (specific element of each organ in relation to its function) and the mesenchymal compartment (transversal element providing the most appropriate support and environment for any organ). This latter plays a fundamental role in tissue architecture which supports optimal organ functions. GOT-IT focuses its research on this architecture, the associated mechanical constraints, and at the cellular level studies mesenchymal stem/stromal cells (MSC) as an orchestrator and key indicator of tissue homeostasis and as a strategic target for tissue regeneration.
This multidisciplinary group proposes an original and holistic approach from the creation of numerical and micro-physiological models to the setting up of clinical trials. To do so, the team relies on state-of-the-art technologies such as artificial intelligence but also mechanobiology (AFM), microscopy (biphotonics and light sheet microscopy, spectral analysis, …etc), 3D tissue engineering. Moreover, GOT-IT members have set up the unique ISO standards French academic platform for quality control of MSCs as well as the unique European academic platform labelled for bio-distribution and biosafety studies of Advanced Therapeutical Médicinal Products (ATMP) within national infrastructure ECellFrance.
Our team has also played a key role in the development and structuring of the INSPIRE scientific project, which aims to better understand human functional decline and to propose rejuvenative therapies to prevent elderly dependency.
The team remains a leader through its strong involvement in innovative biotherapies and bioproduction systems, in research, in R&D, in the development of an economic sector in the Occitanie region and in training systems for associated professions.
Louis Casteilla
PhD - PR UPS-UT3
Valérie Planat
PhD - PR UPS-UT3
Paul Monsarrat
PU-PH Odontology UPS-CHU
Marielle Ousset
PhD - CRCN CNRS
Philippe Kemoun
PU-PH Odontology UPS-CHU
Anne Lorsignol
PhD - PR UPS-UT3
Corinne Lorenzo
PhD - IR CNRS
Jenny Paupert
PhD - MCF UPS-UT3
Isabelle Raymond
PhD - PR ENVT
Noélie Davezac
PhD - PR UPS-UT3
Béatrice Cousin
DR CNRS
Christophe Guissard
BS - AI UPS-UT3
Olivier Abbo
PU-PH - Pediatric surgery - UPS-CHU
Chiara Cecchin
Assistant Professor Odontology
Margot Tertrais
PhD - IR CHU Toulouse
Alexis Coullomb
Post-Doc CNRS
Selma Ben Hammamia-Ouni
MS - PhD student
Olivier Deny
DDS – PhD student
Emilie Leroy
IE CHU Toulouse
Benoit Chaput
PU-PH - Plastic surgery - UPS-CHU
Alessandra Bura-Riviere
PU-PH - Vadscular medicine - UPS-CHU
Laetitia Pieruccioni
MS - PhD student
Pilar Oreja-Fuentes
AI UPS-UT3
Marion Cescato
MS - AI CNRS
Mélissa Parny
PhD - IR CNRS
Jeanne Minvielle-Moncla
MS - PhD student
Laura Maligne
IR CNRS
Alexandra Dumond
IR INSERM
Hermes Desgrez-Dautet
MS - PhD student
Corentin Coustham
PhD - IR CNRS
Clément Capdeville
MS - PhD student
Chloé Jessu
IE CNRS
Pierre-Alexandre Grott
MS - PhD student
Laurence Vaysse
PhD - IR INSERM
PUBLICATIONS
REVIEW
PATENTS
PUBLICATIONS
Main Publications (5 last years) :
- mosna reveals different types of cellular interactions predictive of response to immunotherapies and survival in cancer.
Coullomb A, Foulon C, van Haastrecht B, Monsarrat P, Pancaldi V. Mol Cell Proteomics. 2026 Feb 25:101536. doi: 10.1016/j.mcpro.2026.101536.
- Age-related evolution of human gingiva towards a fibrotic-like connective phenotype.
Cecchin-Albertoni C, Deny O, Pieruccioni L, Ousset M, Oreja-Fuentes P, Arnaud E, Guissard C, Casteilla L, Planat-Bénard V, Kémoun P, Monsarrat P. Sci Rep. 2025 Nov 25;15(1):45298. doi: 10.1038/s41598-025-29089-w.
- A single-graph visualization to reveal hidden explainability patterns of SHAP feature interactions in machine learning for biomedical issues
Félix Furger , Miguel Thomas , Julien Aligon, Emmanuel Doumard, Cyrille Delpierre, Louis Casteilla, Paul Monsarrat. Plos Comp Sys. 2025 Sep, https://doi.org/10.1371/journal.pcsy.0000060
- EMito-Metrix enables automated evaluation of mitochondrial morphology across species.
Morin E, Doumard E, Hartnell LM, Salegi Ansa B, Leduc-Gaudet JP, Quillien A, Nakhle J, Ethuin S, Goudounèche D, Payré B, Soldan V, Balor S, Mattout A, Rouquette J, Dubois L, Sengenès C, Planat V, Casteilla L, Yart A, Dray C, Aligon J, Ferrucci L, Duchesne É, Hussain SNA, Gouspillou G, Formentini L, Mourier A, Baris OR, Valet P, Parpex H, Monsarrat P, Vigneau M, Pradère JP. Nat Metab. 2025 Nov;7(11):2179-2182. doi: 10.1038/s42255-025-01400-z.
- Identification of Functional Cellular Markers Related to Human Health, Frailty and Chronological Age.
Brodeau C, Joly C, Chekroun A, Nakhle J, Blase V, Espagnolle N, Dray C, Yart A, Planat V, Tertrais M, Fassy J, Guyonnet S, Lu WH, de Souto Barreto P, Teste O, Tremblay-Franco M, Tanner KT, Cohen AA, Carriere A, Casteilla L, Ader I; IHU HealthAge/Open Science group. Aging Cell. 2025 Sep;24(9):e70153. doi: 10.1111/acel.70153
- Discernibility in explanations: Designing more acceptable and meaningful machine learning models for medicine.
Wang H, Aligon J, May J, Doumard E, Labroche N, Delpierre C, Soulé-Dupuy C, Casteilla L, Planat-Benard V, Monsarrat P. Comput Struct Biotechnol J. 2025 Apr 23;27:1800-1808. doi: 10.1016/j.csbj.2025.04.021.
- Periodontitis therapy using autologous adipose-derived stromal cells: a double-blind randomized controlled clinical trial in an aged canine model.
Paul Monsarrat , Sara Laurencin-Dalicieux , Geraldine Jourdan, Vincent Blasco-Baque , Marion Bourdens , Emilie Bouhsira , Chiara Cecchin-Albertoni , Fabrice Conchou , Pascale Loubieres , Matthieu Minty , Emmanuelle Arnaud , Sophie Dupuis-Coronas, Christophe Guissard , Jade Chaumont , Louis Casteilla , Isabelle Raymond-Letron , Valerie Planat-Benard , Philippe Kemoun. 2024 Oct; doi :10.1016/j.jcyt.2024.10.012
- A computational model reveals an early transient decrease in fiber cross-linking that unlocks adult regeneration.
Pacary A, Peurichard D, Vaysse L, Monsarrat P, Bolut C, Girel A, Guissard C, Lorsignol A, Planat-Benard V, Paupert J, Ousset M, Casteilla L. NPJ Regen Med. 2024 Oct 15;9(1):29. doi: 10.1038/s41536-024-00373-z.
- Acceptability of Allogeneic Mesenchymal Stromal Cell-Based Tissue Engineering for the Treatment of Periodontitis: A Qualitative Study in France.
Riazuelo L, Planat-Bénard V, Vinel A, Laurencin S, Casteilla L, Kémoun P, Marty M, Monsarrat P. Int Dent J. 2025 Apr;75(2):840-848. doi: 10.1016/j.identj.2024.07.1208
- Fibre crosslinking drives the emergence of order in a three-dimensional dynamical network model.
Chassonnery P, Paupert J, Lorsignol A, Séverac C, Ousset M, Degond P, Casteilla L, Peurichard D. R Soc Open Sci. 2024 Jan 31;11(1):231456. doi: 10.1098/rsos.231456.
- Scalable Generation of Pre-Vascularized and Functional Human Beige Adipose Organoids.
Escudero M, Vaysse L, Eke G, Peyrou M, Villarroya F, Bonnel S, Jeanson Y, Boyer L, Vieu C, Chaput B, Yao X, Deschaseaux F, Parny M, Raymond-Letron I, Dani C, Carrière A, Malaquin L, Casteilla L. Adv Sci (Weinh). 2023 Sep 20:e2301499. doi: 10.1002/advs.202301499.
- Explainable machine learning framework to predict personalized physiological aging.
Bernard D, Doumard E, Ader I, Kemoun P, Pagès JC, Galinier A, Cussat-Blanc S, Furger F, Ferrucci L, Aligon J, Delpierre C, Pénicaud L, Monsarrat P, Casteilla L. Aging Cell. 2023 Aug;22(8):e13872. doi: 10.1111/acel.13872.
- Characterization and Safety Profile of a New Combined Advanced Therapeutic Medical Product Platelet Lysate-Based Fibrin Hydrogel for Mesenchymal Stromal Cell Local Delivery in Regenerative Medicine.
Canceill T, Jourdan G, Kémoun P, Guissard C, Monsef YA, Bourdens M, Chaput B, Cavalie S, Casteilla L, Planat-Bénard V, Monsarrat P, Raymond-Letron I. Int J Mol Sci. 2023 ; 24(3):2206. doi: 10.3390/ijms24032206
- Periostin Plasma Levels and Changes on Physical and Cognitive Capacities in Community-Dwelling Older Adults.
Sánchez-Sánchez JL, Ader I, Jeanson Y, Planat-Benard V, Vellas B, Casteilla L, de Souto-Barreto P. J Gerontol A Biol Sci Med Sci. 2023 ; 78(3):424-432. doi: 10.1093/gerona/glac226.
- A quantitative approach for the comparison of additive local explanation methods.
Doumard E, Aligon J, Escriva E, Excoffier JB, Monsarrat P , Soulé-Dupuy S. Information Systems, 2023
- A Spectral Principal Component Analysis-Based Framework for Composite Hard/Soft Tissue Fluorescence Image Investigation.
Piriou M, Lorenzo C, Raymond-Letron I, Coronas-Dupuis S, Pieruccioni L, Rouquette J, Guissard C, Chaumont J, Casteilla L, Planat-Benard V, Kemoun P, Monsarrat P. Front Physiol. 2022 ; 13:899626. doi: 10.3389/fphys.2022.899626.
- Systemic Periodontal Risk Score Using an Innovative Machine Learning Strategy: An Observational Study.
Monsarrat P, Bernard D, Marty M, Cecchin-Albertoni C, Doumard E, Gez L, Aligon J, Vergnes JN, Casteilla L, Kemoun P. J Pers Med. 2022 ; 12(2):217. doi: 10.3390/jpm12020217.
- Pain sensing neurons promote tissue regeneration in adult mice.
Rabiller L, Labit E, Guissard C, Gilardi S, Guiard BP, Moulédous L, Silva M, Mithieux G, Pénicaud L, Lorsignol A, Casteilla L, Dromard C. NPJ Regen Med. 2021 ; 6(1):63. doi: 10.1038/s41536-021-00175-7.
- Healthy Aging Biomarkers: The INSPIRE’s Contribution.
Ader I, Pénicaud L, Andrieu S, Beard JR, Davezac N, Dray C, Fazilleau N, Gourdy P, Guyonnet S, Liblau R, Parini A, Payoux P, Rampon C, Raymond-Letron I, Rolland Y, de Souto Barreto P, Valet P, Vergnolle N, Sierra F, Vellas B, Casteilla L. J Frailty Aging. 2021 ; 10(4):313-319. doi: 10.14283/jfa.2021.15.
- Driving regeneration, instead of healing, in adult mammals: the decisive role of resident macrophages through efferocytosis.
Rabiller L, Robert V, Arlat A, Labit E, Ousset M, Salon M, Coste A, Da Costa-Fernandes L, Monsarrat P, Ségui B, André M, Guissard C, Renoud ML, Silva M, Mithieux G, Raymond-Letron I, Pénicaud L, Lorsignol A, Casteilla L, Dromard Berthézène C, Cousin B. NPJ Regen Med. 2021 ; 6(1):41. doi: 10.1038/s41536-021-00151-1.
- The INSPIRE Bio-Resource Research Platform for Healthy Aging and Geroscience: Focus on the Human Translational Research Cohort (The INSPIRE-T Cohort).
Guyonnet S, Rolland Y, Takeda C, Ousset PJ, Ader I, Davezac N, Dray C, Fazilleau N, Gourdy P, Liblau R, Parini A, Payoux P, Pénicaud L, Rampon C, Valet P, Vergnolle N, Andrieu S, de Souto Barreto P, Casteilla L, Vellas B. J Frailty Aging. 2021;10(2):110-120. doi: 10.14283/jfa.2020.3
- Find all our publications here.
REVIEW
- The oral organ: A new vision of the mouth as a whole for a gerophysiological approach to healthy aging.
Cecchin-Albertoni C, Deny O, Planat-Bénard V, Guissard C, Paupert J, Vaysse F, Marty M, Casteilla L, Monsarrat P, Kémoun P. Ageing Res Rev. 2024 Aug;99:102360. doi: 10.1016/j.arr.2024.102360
- A gerophysiology perspective on healthy ageing.
Kemoun P, Ader I, Planat-Benard V, Dray C, Fazilleau N, Monsarrat P, Cousin B, Paupert J, Ousset M, Lorsignol A, Raymond-Letron I, Vellas B, Valet P, Kirkwood T, Beard J, Pénicaud L, Casteilla L. Ageing Res Rev. 2022 ; 73:101537. doi: 10.1016/j.arr.2021.101537
- The nervous system and adipose tissues: a tale of dialogues.
A Lorsignol, L Rabiller, E Labit, L.Casteilla, L Pénicaud. American Journal of Physiology-Endocrinology and metabolism. doi.org/10.1152/ajpendo.00115.2023
- Periodontal Cell Therapy: A Systematic Review and Meta-analysis.
Dubuc A, Planat-Bénard V, Marty M, Monsarrat P, Kémoun P. Adv Exp Med Biol. 2022 ; 1373:377-397. doi: 10.1007/978-3-030-96881-6_20.
- Editorial: MSC Communication in Physiological and Pathological Settings.
Bourin P, Gimble JM, Casteilla L, Salgado A. Front Cell Dev Biol. 2022 ; 10:909550. doi: 10.3389/fcell.2022.909550.
- Cell Aggregate Assembly through Microengineering for Functional Tissue Emergence.
Eke G, Vaysse L, Yao X, Escudero M, Carrière A, Trevisiol E, Vieu C, Dani C, Casteilla L, Malaquin L. Cells. 2022 ; 11(9):1394. doi: 10.3390/cells11091394.
- Tissue Regeneration: The Dark Side of Opioids.
Berthézène CD, Rabiller L, Jourdan G, Cousin B, Pénicaud L, Casteilla L, Lorsignol A. Int J Mol Sci. 2021 ; 22(14):7336. doi: 10.3390/ijms22147336.
- Lactate Fluxes and Plasticity of Adipose Tissues: A Redox Perspective.
Lagarde D, Jeanson Y, Portais JC, Galinier A, Ader I, Casteilla L, Carrière A. Front Physiol. 2021 ; 12:689747. doi: 10.3389/fphys.2021.689747.
- MSCs and Inflammatory Cells Crosstalk in Regenerative Medicine: Concerted Actions for Optimized Resolution Driven by Energy Metabolism.
Planat-Benard V, Varin A, Casteilla L. Front Immunol. 2021 ; 12:626755. doi: 10.3389/fimmu.2021.626755.
- Endogenous Mobilization of Mesenchymal Stromal Cells: A Pathway for Interorgan Communication?
Girousse A, Mathieu M, Sastourné-Arrey Q, Monferran S, Casteilla L, Sengenès C. Front Cell Dev Biol. 2021 ; 8:598520. doi: 10.3389/fcell.2020.598520.
PATENTS
- DIGITAL TISSUE REPAIR MODEL – WO2025133663 –
Peurichard D, Casteilla L, Ousset M, Lorsignol A, Paupert J, Vaysse L, Pacary A
- INTERFACE DEDICATED TO PERSONALISED PHYSIOLOGICAL AGE PREDICTION (PPA) – IDDN.FR.001.160001.000.S.C.2024.000.31230 –
Casteilla L, Aligon J, Monsarrat P, Furger F
- METHODS FOR PREDICTING THE HEALTH STATE OF A SUBJECT FROM FIBROBLASTS – EP24306153.8 (2024) –
Ader I, Guyonnet S, Vellas B, Casteilla L, Brodeau C
- METHOD FOR PREPARING A 3D PREVASCULARISED ADIPOSE TISSUE CONSTRUCT AND ITS USES – WO2024160980 –
Casteilla L, Carrière A, Malaquin L, Dani C, Vaysse L, Escudero M, Eke G
- PROCESSES FOR GENERATING PREVASCULARISED 3D CELL AGGREGATES -WO2024133285 –
Casteilla L, Carrière A, Malaquin L, Dani C, Vaysse L, Escudero M, Eke G
- METHOD FOR IDENTIFYING REACTIVE OXYGEN SPECIES – EP4439067 (2024) –
Coustham C, Merabet N, Bordeneuve-Guibe J, Davezac N
- METHOD FOR DETERMINING THE PHYSIOLOGICAL AGE OF A SUBJECT – WO2023180436 –
Casteilla L, Ader I, Kemoun P, Aligon J, Monsarrat P, Cussat-Blanc S, Bernard D, Doumard E (2023)
- PROCESS TO OBTAIN HUMAN BROWN/BEIGE ADIPOCYTES – WO2017009263 –
Deschaseaux F, Guilloton F, Muller S, Carrière A, Casteilla L, Sensebé L.
- MULTIPLE SAMPLE HOLDER FOR SPIM – USD797831S (2017), EP002624197 (2015) –
Lorenzo C, Lobjois V, Ducommun B.
- USE OF CELLS DERIVED FROM ADIPOSE TISSUE TO INDUCE THE FORMATION OF A FUNCTIONAL VASCULAR NETWORK – WO2005025584 –
Casteilla L, Silvestre JS, Planat-Benard V, Levy B, Penicaud L, Tedgui A
RESPINE European Project
RESPINE is a project funded by Horizon 2020 which is the framework program for research and innovation of the European Union.
Occitanie Region/FEDER project
2019-2022: INSPIRE – Geroscience Translational Research Platform to Support Healthy Aging
2019-2021: CARDIOPREDICT Human ventricular cardiomyocytes predictive of toxicity and cardiac pharmacology, operational program READYNOV SANTE
ANR Projects
Projects funded by the National Research Agency
Partenaires SCIENTIFIQUES
- P. Degond (Imperial College London, London)
- D. Peurichard (INRIA, Paris)
- C. Maugis-Rabusseau (IMT, Toulouse)
- L. Malaquin, C. Thibault, E. Dague – Equipe Elia (LAAS,Toulouse)
- S. Cussat-Blanc (IRIT, Toulouse)
- A. Bonnaffoux (VIDIUM, Lyon)
- F. Plouraboué (IMFT, Toulouse)
- C. Soulé-Dupuy (IRIT, Toulouse)
- Faculty of Odontology of Paul Sabatier University of Toulouse
- Toulouse Institute of Oral Sciences and Medicine
- Toulouse University Hospital Center
- A.-F. Mingotaud – Equipe Ideas (IMRCP, Toulouse)
soutiens financiers
