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GOT-IT

Louis Casteilla
Valérie Planat-Benard

GUIDED SELF-ORGANIZATION OF TISSUE FOR INNOVATIVE THERAPEUTICS

A multidisciplinary approach to study tissue degeneration and regeneration processes in adult mammals and during aging

Set up Advanced therapy medicinal products (ATMP) for regenerative and rejuvenating strategies

Research

Organs/tissues are ecosystems resulting from a dynamic coordination between the parenchymal compartment (specific element of each organ in relation to its function) and the mesenchymal compartment (transversal element providing the most appropriate support and environment for any organ). This latter plays a fundamental role in tissue architecture which supports optimal organ functions. GOT-IT focuses its research on this architecture, the associated mechanical constraints, and at the cellular level studies mesenchymal stem/stromal cells (MSC) as an orchestrator and key indicator of tissue homeostasis and as a strategic target for tissue regeneration.

This multidisciplinary group proposes an original and holistic approach from the creation of numerical and micro-physiological models to the setting up of clinical trials. To do so, the team relies on state-of-the-art technologies such as artificial intelligence but also mechanobiology (AFM), biphotonics microscopy (light sheet microscopy, spectral analysis, …etc), 3D tissue engineering. Moreover, GOT-IT members have set up the unique ISO standards French academic platform for quality control of MSCs as well as the unique European academic platform labelled for bio-distribution and biosafety studies of Advanced Therapeutical Médicinal Products (ATMP) within national infrastructure ECellFrance.

Our team has also played a key role in the development and structuring of the INSPIRE scientific project, which aims to better understand human functional decline and to propose rejuvenative therapies to prevent elderly dependency.

The team remains a leader through its strong involvement in innovative biotherapies and bioproduction systems, in research, in R&D, in the development of an economic sector in the Occitanie region and in training systems for associated professions.

team members

Louis Casteilla

PhD - PR UPS-UT3

Valérie Planat

PhD - MCF UPS-UT3

Frédéric Deschaseaux

CR EFS

Christophe Guissard

BS - AI UPS-UT3

Philippe Kemoun

PU-PH Odontology UPS-CHU

Corinne Lorenzo

PhD - IR CNRS

Anne Lorsignol

PhD - PR UPS-UT3

Paul Monsarrat

PU-PH Odontology UPS-CHU

Marielle Ousset

PhD - CRCN CNRS

Jean-Christophe Pagès

PU-PH Medicine - UPS-CHU

Jenny Paupert

PhD - MCF UPS-UT3

Isabelle Raymond

PhD - PR ENVT

Laurence Vaysse

PhD - IR INSERM

Olivier Abbo

PU-PH - Pediatric surgery - UPS-CHU

Clémence Bolut

MS - PhD student
HappyMan

Benoit Chaput

PU-PH - Plastic surgery - UPS-CHU

Alessandra Bura-Riviere

PU-PH - Vadscular medicine - UPS-CHU

Margot Tertrais

PhD - IR CHU Toulouse

Emilie Leroy

IE CHU Toulouse

Chiara Cecchin

DDS – PhD student

Divyendu Valappil

PhD - IR CNRS

Selma Ben Hammamia-Ouni

MS - IE CNRS

Olivier Deny

DDS – PhD student

Agnès Emans

IE CNRS

Emmanuel Doumard

MS - PhD student

Miguel Thomas

MS - PhD student

Haomiao Wang

MS - PhD student

Anastasia Pacary

MS - PhD student

Victorien Arnaud

MS - PhD student

Pilar Oreja-Fuentes

AI UPS-UT3

Duha Alioglu

PhD - IR CNRS

Félix Furger

IR INSERM

Mélissa Parny

PhD - IR CNRS

Jocelyn Le Goff

AI CNRS

Mélissa Martinez

IR CNRS

Jeanne Minvielle-Moncla

MS - PhD student

Mélanie Escudero

MS - PhD student

Pauline Chassonery

MS - PhD student

Marion Cescato

MS - AI CNRS

Publications

FOUNDING

RESPINE European Project


RESPINE is a project funded by Horizon 2020 which is the framework program for research and innovation of the European Union.

Occitanie Region/FEDER project

2019-2022: INSPIRE – Geroscience Translational Research Platform to Support Healthy Aging

2019-2021: CARDIOPREDICT Human ventricular cardiomyocytes predictive of toxicity and cardiac pharmacology, operational program READYNOV SANTE

BPI France

 

ANR Projects

Projects funded by the National Research Agency

Les partenaires de l'équipe

Partenaires SCIENTIFIQUES
soutiens financiers