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GOT-IT

Louis Casteilla
Valérie Planat-Benard

GUIDED SELF-ORGANIZATION OF TISSUE FOR INNOVATIVE THERAPEUTICS

A multidisciplinary approach to study tissue degeneration and regeneration processes in adult mammals and during aging

Set up Advanced therapy medicinal products (ATMPs) for regenerative and rejuvenating strategies

Research

Organs/tissues are ecosystems resulting from a dynamic coordination between the parenchymal compartment (specific element of each organ in relation to its function) and the mesenchymal compartment (transversal element providing the most appropriate support and environment for any organ). This latter plays a fundamental role in tissue architecture which supports optimal organ functions. GOT-IT focuses its research on this architecture, the associated mechanical constraints, and at the cellular level studies mesenchymal stem/stromal cells (MSC) as an orchestrator and key indicator of tissue homeostasis.

This multidisciplinary group proposes an original and holistic approach from the creation of numerical and micro-physiological models to the setting up of clinical trials. To do so, the team relies on state-of-the-art technologies such as mechanobiology (AFM), biophotonics (light sheet microscopy, spectral analysis, …etc), 3D tissue engineering and biomaterials. Moreover, GOT-IT members have set up the unique ISO standards French platform for quality control of MSCs as well as the unique European academic platform labelled for bio-distribution and biosafety studies of ATMPs (LabHPEC) within national infrastructure ECellFrance.

Our team has also played a key role in the development and structuring of the INSPIRE scientific project, which aims to better understand human functional decline and to propose rejuvenative therapies to prevent elderly dependency.

team members

Louis Casteilla

PhD - PR UPS-UT3

Valérie Planat

PhD - MCF UPS-UT3

Frédéric Deschaseaux

CR EFS

Christophe Guissard

BS - AI UPS-UT3

Philippe Kemoun

PhD - PR UPS-UT3

Corinne Lorenzo

PhD - IR CNRS

Anne Lorsignol

PhD - PR UPS-UT3

Paul Monsarrat

PhD - PR UPS-UT3

Marielle Ousset

PhD - CRCN CNRS

Jean-Christophe Pagès

PhD - PR UPS-UT3

Jenny Paupert

PhD - MCF UPS-UT3

Isabelle Raymond

PhD - PR ENVT

Laurence Vaysse

PhD - IR INSERM

Anastasia Pacary

MS - PhD student

Clémence Bolut

MS - PhD student

Mélanie Escudero

MS - PhD student

Pauline Chassonery

MS - PhD student

Margot Tertrais

PhD - IR CHU Toulouse

Emilie Leroy

IE CHU Toulouse

Chiara Cecchin

DDS – PhD student

Divyendu Valappil

PhD - IR CNRS

Selma Ben Hammamia-Ouni

MS - IE CNRS

Olivier Deny

IR - INSERM

Agnès Emans

IE CNRS

Adeline Girel

IE CNRS

Emmanuel Doumard

MS - PhD student

Miguel Thomas

MS - PhD student

Haomiao Wang

MS - PhD student

Olivier Abbo

Victorien Arnaud

MS - PhD student

Publications

Les partenaires de l'équipe

Partenaires SCIENTIFIQUES
soutiens financiers