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STROMAGICS

Coralie Sengenes

Repair/Regenerate via the circulation of mesenchymal stromal cells between organs

From their development to the end of their lives, most organisms experience a gradual decline in their regenerative capacity. Schematically, each organ can be divided up into a functional compartment, the parenchyma, and a stromal compartment, the stroma, which supports the parenchymal cells of the organ. In the stroma, there is a population of cells with multiple differentiation capacities, the mesenchymal stromal cells (MSCs). MSCs exhibit a strong regenerative potential and are considered key players in the regeneration of damaged tissue. Adipose tissue is, to date, the richest reservoir of MSCs where they are called adipose stromal cells or ASCs. Unexpectedly, this ASC reservoir can be mobilized in response to stresses of inflammatory and/or lesional origin. Once released, ASCs infiltrate the damaged/inflamed organ and participate in its remodeling and/or regeneration.

How are ASCs recruited? What are the functional characteristics of mobilized ASCs? How does the contribution of ASCs to regeneration evolve according to age-related frailty ? All these questions remain unanswered.

The STROMAGICS project consists in deciphering the relationship between stromal dynamics and age-related functional decline. Our scientific objectives are the following:

  1. To identify the molecular and cellular characteristics of mobilizable ASCs and the mechanisms controlling and enabling this original dynamics
  2. To characterize this dynamic in the context of aging

research areas

team members

Coralie Sengenes

Team leader - PhD

Amandine Girousse

CR - PhD CNRS

André Mireille

Assistant Engineer CNRS

Corinne Barreau

PhD

Xavier Contreras

PhD - CR Inserm

Cécile Dromard Berthezene

PhD
DUCOMM~1

Bernard Ducommun

JOURDAN Géraldine

Géraldine Jourdan

MATHIE~1

Maxime Mathieu

Sylvie Monferran

PhD Associate Professor

Rémi Touron

Biological technician CNRS
user

Lucie Barthe

CINTAS Pascal

Pascal Cintras

user

Odile Mondesert

user

Luc Penicaud

user

Manel Hnia

Publications

Les partenaires de l'équipe

Partenaires SCIENTIFIQUES
soutiens financiers