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Cédric Dray / Armelle Yart

Metabolic interplays and age-related loss of function

Team Metabolink

During lifespan, environmental fluctuations consistently forced organism and cells to develop metabolic flexibility in order to maintain their energy homeostasis.

In this context, many aspects of cellular/tissue metabolism changes are driven by redox metabolism as well as inter-cellular and inter-organs metabolic interactions that are fundamental to maintain tissue and whole body energetic homeostasis. Altogether, these parameters are in constant adaptation and represent the metabolic resilience of cell (cell capacity to face metabolic alterations).

Cibler le dialogue métabolique systémique et local afin d’améliorer la flexibilité métabolique
Targeting systemic and local metabolic dialogue to improve metabolic flexibility


We hypothesized that metabolic resilience directs the ability of the aging organism to maintain the main metabolic functions (storage, utilization and release of energy) necessary to perform towards healthy-aging or dependence when disrupted.

Our aim is to investigate the role and the regulation of local/systemic metabolic dialogue within a tissue (mesenchyma/parenchyma) and between metabolic tissues (adipose tissues/muscle/liver) by focusing on intracellular changes in metabolic pathways and redox state triggering major modifications of secretion and cell production. This will allow identifying new mechanisms that contribute, when defective, to the onset or aggravation of age-related diseases (sarcopenia, metabolic diseases) that could represent therapeutic targets of interest.


research areas

team members

Ageing, friality, cancer, redox metabolism, hypoxia, metabolic flexibility, lipids, fibroblasts, mesenchymal stem cells

ADER Isabelle

Isabelle Ader-Perarnau

Molecular biology, cell culture ( mouse/human; normoxia/Hypoxia), flux cytometry

Brodeau Chloé

Chloé Brodeau

Redox metabolism, Mitochondria, ROS, Adipose tissue, Plasticity, brite and brown adipocytes, Lactate sensing and signaling

Carriere Audrey

Audrey Carriere-Pazat

Ageing, haptoglobine, sarcopenia, senescence

Catennaci Marie

Marie Catenacci

Cellular biology, molecular biology, cell culture

Chekroun Anais

Anais Chekkoun

Apelin, sarcopenia, ageing, adipokines, myokines, metabolism

Cedric dray

Cédric Dray

Redox metabolism, metabolic challenge, human biological diagnostic, human nutrition, coenzymes


Anne Galinier

Metabolism, adipocytes, metabolomic, fluxomic, isotopic tracing in vitro/in vivo, cell culture (hypoxia), mitochondrial activity

Jeanson Yannick

Yannick Jeanson

Metabolism, adipose tissue, apelin, adipokines, obesity, type 2 diabetes

Laurell Isabelle 2

Isabelle Laurell

Noonan syndrom, hormones, metabolism and muscle physiology, inter-organ communication

Mazeyrie Laurène

Laurène Mazeyrie

In vivo functional exploration, metabolic phenotyping, surgery

S Le Gonidec

Sophie Le Gonidec

Anesthesia, reanimation, pain

Minville Vincent done

Vincent Minville

Ageing, sarcopenia, Zebrafish, mitochondrial metabolism

Morin Elena

Elena Morin

Ophélie Pereira

Ophélie Pereira

Cognition, obesity, adipose tissue


Vincent Pey

Apelin/APJ, obesity, adipokines, diabetes, ageing

Valet Ph

Philippe Valet

Liver, adipose tissue, macrophages, metabolism, inflammation, ageing

Pradère JP

Jean-Philippe Pradere

metabolism, metabolic network, metabolomic, fluxomic, metabolic modelisation

Jean-Charles Portais

Jean-Charles Portais

Surgery, cognition, obesity, adipose tissue, inflammation


Clémence Tropis


Growth, bone, metabolism, endocrinology, rare diseases, translationnal research

Edouard T

Thomas Edouard


Fabien Pillard


Marie Sallese

Metabolism, rare diseases, translational research, signalisation, senescence

YART Armelle

Armelle Yart


Les partenaires de l'équipe

soutiens financiers