Louis Casteilla is full professor at animal physiology in the Faculty of Science and Engineering of Toulouse III university. He is the co-leader of RESTORE Institute Team 4. For his PhD, his first work was on the development and plasticity of adipose tissues. He co-discovered and patented with V Planat in 2004 the great regenerative angiogenic properties of adipose derived stroma/stem cells (ASC)[1][2]. He translated this discovery to the bedside for the first clinical trial to test the effect of ASC on critical limb ischemia [3]. From this seminal work, he has been focused his interest and investigations on regeneration in adult mammals and the development of ASC based ATMP. He set-up and co-manages with V Planat-Benard the unique quality control facility of the French infrastructure EcellFrance dedicated to the development of MSC-based ATMP. Recent work aims to decipher the decisive rules that govern the maintain and the restoration of tissue structure and function during the aging process [4] through integrated approaches and numerical model development.
[1] Plasticity of human adipose lineage cells toward endothelial cells: physiological and therapeutic perspectives. Planat-Bénard V. et al. Circ. 2004. doi: 10.1161/01.CIR.0000114522.38265.61
[2] Aging-related decrease of human ASC angiogenic potential is reversed by hypoxia preconditioning through ROS production. De Barros S. et al. Mol. Ther. 2013. doi: 10.1038/mt.2012.213.
[3] A phase I trial: the use of autologous adipose-derived stroma/stem cells to treat patients with non-revascusuclarizable Critical Limb Ischemia. Bura-Rivière A. et al. Cytotherapy, 2014. doi: 10.1016/j.jcyt.2013.11.011
[4] A gerophysiology perspective on healthy ageing. Kemoun P et al. Ageing Res Rev. 2022. doi: 10.1016/j.arr.2021.101537
