White adipose tissue (WAT) is a central organ of lipid and glucose metabolism that impacts systemic energy homeostasis. WAT actively senses nutritional changes and accordingly stores extra energy in the form of triglycerides or supplies nutrients to other organs.
Also, WAT regulates whole-body energy metabolism by communicating locally and with distant tissues by secreting signaling molecules such as adipokines, lipokines, metabolites, and exosomes. In obesity, multiple insults promote aberrant gene expression in WAT and lead to WAT dysfunction. Obesity is one of the major risk factors for the development of metabolic diseases such as cardiovascular diseases, type 2 diabetes, and atherosclerosis as well as cancer.
Accordingly, significant advances have been made over the past few decades in the understanding of obesity-induced aberrant WAT remodeling and its pathophysiology concerning obesity-related metabolic disorders. In this presentation, I will discuss the heterogeneity of adipose tissue and energy homeostasis with crosstalk between multiple cell types.
Pour en apprendre davantage
Jae Bum Kim, Ph. D.
Director, Center for Adipocyte Structure & Function, National Leading Researcher Initiatives
Professor of Biological Sciences, Institute of Molecular Biology and Genetics
Seoul National University, Seoul, Korea
