Cytek Biosciences spectral Flow Cytometry :A full spectrum of solutions from immune cells deep characterization to small particles sorting. The Cytek Aurora™ CS system was built with the scientist in mind, leveraging the power of Full Spectrum Profiling™ technology in a flexible and easy-to-use platform that meets the diverse needs of your laboratory, while delivering the sorting functionality you would expect from […]

Interorgan communication: a drosophila perspective Norbert Perrimon wants to understand how cells, tissues, and organs communicate during development. Working in Drosophila, Perrimon’s lab group uses techniques such as genome-wide RNAi and CRISPR screening and large-scale mass spectrometry to identify components of signaling networks and points of intersection, or “cross-talk nodes,” between signaling pathways that produce […]

Adipose Tissue Remodeling and Its Role in Energy Metabolism White adipose tissue (WAT) is a central organ of lipid and glucose metabolism that impacts systemic energy homeostasis. WAT actively senses nutritional changes and accordingly stores extra energy in the form of triglycerides or supplies nutrients to other organs. Also, WAT regulates whole-body energy metabolism by […]

Organoid human cancer immunity model in motion Dr Anne Rios will present a dynamic 3D imaging and integrated transcriptomics platform; BEHAV3D5, that has been developed to exploit immune-organoid co-cultures for understanding and improving the dynamic mode-of-action of engineered T cells in a patient personalized manner. Applied to various solid tumor types modeled with patient derived […]

Spatial heterogeneity of tumor-associated macrophages Mots clés : Cellules myéloïdes – Inflammation – Infection – Cancer – Chemokines – Imagerie en direct Le travail de l’équipe du Dr BOISSONNAS se concentre sur l’origine et la fonction des cellules myéloïdes dans les maladies infectieuses et le cancer. Il s’agit de déchiffrer la régulation des activités pro […]

Cardioimmunologie: aspects mécanistiques et thérapeutiques Les travaux de recherche de son équipe visent à identifier des mécanismes moléculaires et cellulaires qui contrôlent les événements clés du remodelage tissulaire post-ischémique et qui offrent des perspectives thérapeutiques puissantes en matière de revascularisation. Leurs travaux se focalisent notamment sur : 1) le rôle de l’immunité innée et adaptative […]

Un modèle philosophique pour penser l’adaptabilité biologique S’inscrivant dans la lignée de la pensée de Bergson et, plus généralement, de la philosophie française de la vie, il mène ses recherches en philosophie de la biologie, d’un point de vue indissociablement épistémologique et métaphysique. S’inspirant du concept d’émergence diachronique, il tente ainsi d’articuler une approche non […]

Building intestinal tissue using human pluripotent stem cells The team Dr MAHÉ leads tries to create integrated human gut models derived from human pluripotent stem cells. His group uses these models with complex environmental cues, including mechanics and luminal factors (microbiota, nutrients). His group builds on these models to elucidate novel functions and mechanisms of […]

Mitochondrial membrane remodelling and tissue sequelae Les travaux de recherche de l’équipe du Dr WAI visent à mieux comprendre l’interaction complexe de la dynamique et du métabolisme des mitochondries dans la santé et la maladie.  Sa recherche s’appuie sur une science de pointe dans les domaines de la biologie cellulaire et de la biochimie des […]

Myeloid cell fusion in physiological and pathological context: tunneling nanotubes call the tune Macrophages are innate immune cells that migrate and are present in all tissues to maintain the immune surveillance. They are targets for pathogens and ingest particles such as bacteria or dead cells, a process called phagocytosis. Our team focuses on the mechanisms […]