Laure Le Pelletier
My research interests focus on two main areas: cell invasion and tumor resistance to standard anticancerous therapies. In several tumor cell lines (leukemia, glioblastoma, cancer stem cells) and preclinical models, I have deciphered the signaling pathways involved in these two processes, focusing on the role of integrins and RhoGTPases. I have shown that some of these molecular actors are involved in invasion and resistance processes and can activate them, giving a selective advantage to tumor cells. More recently, I joined the Stromalab to become interested in adipose stromal cell migration. There, I study more specifically the fascinating ability of adipose stromal cells to migrate notably during muscle regeneration.
Molecular biology, cell biology and oncology at the Faculty of Pharmaceutical Sciences (Toulouse III University), from the first year common to health studies (PACES/PASS/LAS) to Master
Editor for International Journal of Molecular Sciences
Publications / Patents
Patent: EP18305148.1. WO2019158512 Toulas C, Moyal E, Monferran S. Methods for the prognosis and the treatment of glioblastoma.
Mouly L, Gilhodes J, Lemarié A, Cohen-Jonathan Moyal E, Toulas C, Favre G, Sordet O, Monferran S. (2019) The RND1 Small GTPase: Main Functions and Emerging Role in Oncogenesis. Int J Mol Sci 20(15).
Mouly L, Mamouni K, Gence R, Cristini A, Cherier J, Castinel A, Legrand M, Favre G, Sordet O, Monferran S. (2018) PARP-1-dependent RND1 transcription induced by topoisomerase I cleavage complexes confers cellular resistance to camptothecin. Cell Death Disease. 12;9(9):931.
Boyrie S, Delmas C, Lemarié A, Lubrano V, Dahan P, Malric L, Luis J, Gilhodes J, Tosolini M, Mouly L, Lehmann M, Toulas C, Cohen-Jonathan Moyal E, Monferran S. (2018) RND1 regulates migration of human glioblastoma stem-like cells according to their anatomical localization and defines a prognostic signature in glioblastoma. Oncotarget. 9(73):33788-33803.
Malric L, Monferran S, Delmas C, Arnauduc F, Dahan P, Boyrie S, Deshors P, Lubrano V, Ferreira Da Mota D, Gilhodes J, Filleron T, Siegfried A, M. Evrard S, Kowalski-Chauvel A, Cohen-Jonathan Moyal E, Toulas C, Lemarié A. (2018) Inhibiting Integrin β8 to differentiate and radiosensitize Glioblastoma-Initiating cells. Molecular Cancer Research. 17(2):384-397.
Malric L, Monferran S, Gilhodes J, Boyrie S, Dahan P, Skuli N, Sesen J, Filleron T, Kowalski-Chauvel A, Cohen-Jonathan Moyal E, Toulas C, Lemarié A. (2017) Interest of integrins targeting in glioblastoma according to tumor heterogeneity and cancer stem cell paradigm: an update. Oncotarget. 8(49):86947-86968.