Contrôle de la résolution de l’inflammation par les basophiles dans un modèle de lésion cutanée chez la souris âgée Pro-resolution M2-like macrophages are critical for wound healing. Aging-associated systemic chronic inflammation alters their functions and favors the development of chronic wounds, a major morbidity in elderly patients. Basophils, rare circulating granulocytes known for their pro-inflammatory […]

Etiopathology of gingival inflammation: towards a new paradigm based on virus – bacteria synergy Periodontitis is one of the most common human inflammatory condition. This disease is responsible for tooth mobility and tooth loss, and it is also a significant risk factor for dozens of seemingly unrelated systemic illnesses. A polymicrobial dysbiosis model was proposed […]

Lessons for disease learned from cellular ageing: a 3D genome perspective We wish to uncover the rules governing gene expression in response to developmental and extra-cellular cues. Genome architecture is thought to be a major determinant in this. What we strive to understand is how chromatin (re)folds to accommodate responses to such cues in 3D […]

Bénéfices & Applications de la technologie CyTOF pour la cytométrie et l’imagerie tissulaire Avoir la possibilité de monter en puissance dans le nombre de paramètres à étudier simultanément en cytométrie et en imagerie tissulaire est un enjeu crucial pour vos recherches. L’objection majeure à cette escalade est toutes les limites des technologies liées aux fluorochromes […]

Mécano-biologie des tissus hétérogènes par changement d’échelles :application à l’ostéosarcome Collaborations: A. Gomez-Brouchet (PUPH, CRCT), J Sales de Gauzy (PUPH, IMFT), A. Mancini (Ph.D st), A Moreno (Ph.D), M Quintard (DR CNRS, IMFT), P Swider (PR Université de Toulouse, IMFT) Résumé:L’ostéosarcome est une tumeur osseuse primitive qui survient principalement chez les adolescents et les jeunes […]

PET Imaging and Theranostics in the Age of Personalized Medicine With the emergence of theranostics and the expected impact of artificial intelligence on our work, it is an exciting time to be in the field of nuclear medicine. For about 60 years, the Division of Nuclear Medicine at the University of Michigan has been developing […]

Autophagy, a major metabolic regulator involved in AML therapy resistance Malgré l’efficacité des chimiothérapies et l’arrivée de thérapies ciblées, les rechutes restent fréquentes et le pronostic vital des patients atteints de Leucémies Aiguës Myéloïdes (LAM) faible. Il est maintenant admis que la résistance aux traitements des cellules LAM nécessite une adaptation de leur métabolisme. Nous […]

Gastric and intestinal adaptations in response to bariatric surgery and their contribution to glycemic improvement The team gathers physiologists of the gastro-intestinal tract, basic scientists and clinicians (digestive surgeons, gastroenterologists and nutritionists) to develop basic and transitional researches to study gastrointestinal adaptations in response to obesity, surgical remodeling, and nutritional status (undernutrition / malnutrition). More […]

From olfactory organ formation using embryonic, mathematical and microfluidic models to a PhD student mentoring programme with CBI and Femmes & Sciences responses? Julie Batut est biologiste, spécialiste de la neurogenèse ainsi que de l’identité et la forme des cellules au cours du développement embryonnaire. Chercheuse au CNRS, elle étudie la mise en place de […]

Hypothalamic REV-ERB nuclear receptors control diurnal leptin sensitivity and circadian period: implications for diet-induced obesity Résumé de la présentation : Circadian disruption, as occurs in shift work, is associated with metabolic diseases often attributed to a discordance between internal clocks and environmental timekeepers. REV-ERB nuclear receptors are key components of the molecular clock, but their […]